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Nature Immunology (Free subscription) | 21/07/2008
Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5 Nature Immunology 9, 945 (2008). doi:10.1038/ni0808-945 Authors: Folmer Fredslund, Nick S Laursen, Pietro Roversi, Lasse Jenner, Cristiano L P Oliveira, Jan S Pedersen, Miles A Nunn, Susan M Lea, Richard Discipio, Lars Sottrup-Jensen & Gregers R Andersen
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Nature Immunology (Free subscription) | 21/07/2008
Autophagy has been suggested—on the basis of in vitro studies—to be involved in defense against bacterial challenge. A study in drosophila now shows the importance of autophagy in vivo and links a pattern recognition receptor to the autophagy pathway.
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Nature Immunology (Free subscription) | 21/07/2008
The production of inflammatory interleukin 1β after uptake of silica crystals and alum salt or amyloid-β occurs by a process that involves lysosomal destabilization and release of cathepsin B that activates the NLRP3 inflammasome.
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Nature Immunology (Free subscription) | 21/07/2008
New findings show that ERAAP, an endoplasmic reticulum aminopeptidase involved in antigen processing, helps mice survive encounters with a feline-derived parasite.
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Nature Immunology (Free subscription) | 21/07/2008
A key regulator of the balance of signals that activate effector mechanisms versus those that restrain them, β-arrestin 2 mediates the inhibition of natural killer cell cytotoxicity.
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Nature Immunology (Free subscription) | 21/07/2008
Host immunity requires cytotoxic lymphocytes that are able to move toward their targets but are also able to stop after identifying target cells and then establish stable cell-cell contact. A new study shows that separate phosphorylation sites in HS1, an actin cytoskeleton–remodeling factor, can regulate both processes.
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Nature Immunology (Free subscription) | 21/07/2008
The AIDS pandemic is caused by human immunodeficiency virus, which was discovered at the Institut Pasteur in 1983. In May 2008, scientists met in Paris to discuss the progress and setbacks of 25 years of research in this field and to debate future directions.
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Nature Immunology (Free subscription) | 21/07/2008
Despite pessimism in the media surrounding the recent failure of the Merck HIV vaccine, researchers should applaud their achievements and step up to the challenges ahead.
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Nature Immunology (Free subscription) | 18/06/2008
This year marks the 100th anniversary of the Nobel Prize in Physiology or Medicine awarded jointly to Paul Ehrlich and Ilya Metchnikov.
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Nature Immunology (Free subscription) | 18/06/2008
A vibrant and eclectic international immunology meeting recently took place in the Arabian Desert of the United Arab Emirates, in the heart of the Islamic world.
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Nature Immunology (Free subscription) | 18/06/2008
This report presents themes highlighted during the eclectic and stimulating Metchnikoff's Legacy in 2008 meeting hosted at the Institut Pasteur in April 2008 in honor of the 100th anniversary of the 1908 Nobel Prize.
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Nature Immunology (Free subscription) | 18/06/2008
Increasing evidence suggests that immune mechanisms underlie major inflammatory diseases that show no overt microbial etiology. In this context, a 4-day conference of clinical and nonclinical scientists convened in the United Arab Emirates to consider recent research developments in this fast-moving field.
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Nature Immunology (Free subscription) | 18/06/2008
Neutrophils can respond to many chemotactic signals, but how these cells 'prioritize' such signals to react to invading pathogens has remained unclear. The phosphatase PTEN seems to be critical in directing the migration of neutrophils toward their end target in a complex milieu of competing signals.
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Nature Immunology (Free subscription) | 18/06/2008
Additional immune functions of basophils have been identified in recent years. Mack and colleagues add to this growing list by showing that basophils enhance humoral memory responses by producing interleukins 4 and 6 in response to specific antigen.
