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Genetics


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Your Take: Would You Get Genetic Testing?

claMy wife and I once discussed getting genetic testing done to figure out whether our kids would be grow up to become NBA superstars and fund our lavish retirement plans. Anyway, with that plan in mind, I originally planned to spend tens of thousands of dollars to get myself tested by a plethora of different [...]

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Op-Ed: Genetics cannot be employment issue

If you have the breast cancer gene, is an employer justified in not promoting you to a key job out of fear that you’ll get sick? If you have diabetes, controlled by medication, should an employer be able to find that out and not hire you in assumption your health insurance costs will be high? [...]

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Genetics ∩ Sociology ∩ Evolution = Genomic Imprinting

As I have said before biology is quite often the science of exceptions, of variation. Evolutionary biologists spend a great deal of time wondering about the origin of sex , but across vast swaths of the tree of life sex is simply not a consideration. W. D. Hamilton made his name with models of inclusive fitness , but complex social structures are constrained and fully elaborated to only a few branches...

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Gene Expression: Genetics ∩ Sociology ∩ Evolution = Genomic Imprinting

As I have said before biology is quite often the science of exceptions, of variation. Evolutionary biologists spend a great deal of time wondering about the origin of sex, but across vast swaths of the tree of life sex is simply not a consideration. W. D. Hamilton made his name with models of [...]

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Relevant Palin Facts

Most popular governor in America, with an approval rating around 90 percent. A strong fiscal conservative. A lifetime member of the National Rifle Association (hunts and fishes). Staunchly pro-life. (Palin refused to let the results of prenatal genetic testing change her decision to have the baby. “I’m looking at him right now, and I see perfection,” Palin [...]

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Economy catches up with biotech investing

Early in 2008, biotech investment was on a roll. It seemed as though the industry was insulated from many of the problems affecting the rest of the economy. But Robert Dellenbach at Genetic Engineering News observes that the poor economy has caught up with the industry, and that biotech investing could be facing tough times ahead. "Despite an abundance of funding as well as scientific and technological...

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Extended release of adenovirus from silica implants in vitro and in vivo

Extended release of adenovirus from silica implants in vitro and in vivo Gene Therapy advance online publication, August 28, 2008. doi:10.1038/gt.2008.142 Authors: L Kangasniemi, M Koskinen, M Jokinen, M Toriseva, R Ala-Aho, V-M Kähäri, H Jalonen, S Ylä-Herttuala, H Moilanen, U-H Stenman, I Diaconu, A Kanerva, S Pesonen, T Hakkarainen & A Hemminki

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Identification and characterization of multiple splice forms of the human interleukin-23 receptor α chain in mitogen-activated leukocytes

Identification and characterization of multiple splice forms of the human interleukin-23 receptor α chain in mitogen-activated leukocytes Genes and Immunity advance online publication, August 28, 2008. doi:10.1038/gene.2008.64 Authors: S-h Kan, G Mancini & G Gallagher

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Bone marrow cells produce a novel TSHβ splice variant that is upregulated in the thyroid following systemic virus infection

Bone marrow cells produce a novel TSHβ splice variant that is upregulated in the thyroid following systemic virus infection Genes and Immunity advance online publication, August 28, 2008. doi:10.1038/gene.2008.69 Authors: B H Vincent, D Montufar-Solis, B-B Teng, B A Amendt, J Schaefer & J R Klein

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Victor A. McKusick 1921–2008

Victor A. McKusick 1921–2008 Nature Genetics 40, 1037 (2008). doi:10.1038/ng0908-1037 Author: David L Rimoin

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Reply to “Variation in KLK genes, prostate-specific antigen and risk of prostate cancer”

Reply to “Variation in KLK genes, prostate-specific antigen and risk of prostate cancer” Nature Genetics 40, 1035 (2008). doi:10.1038/ng0908-1035 Authors: Rosalind Eeles, Graham Giles, David Neal, Kenneth Muir & Douglas F Easton

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High anxiety

High anxiety Nature Genetics 40, 1038 (2008). doi:10.1038/ng0908-1038 Author: Misha Angrist

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Psychiatric genetics gets a boost

Defining the molecular nature of the genetic risk of psychiatric disorders has been notoriously difficult. Now, a flurry of genome-wide association studies for schizophrenia and bipolar disorder provides preliminary evidence for replicated signals.

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Casting a wider net for diabetes susceptibility genes

Recent successes in identifying loci involved in predisposition to type 2 diabetes have been driven by genome-wide association studies in populations of European descent. A new discovery, using samples of East Asian origin, of diabetes susceptibility variants mapping to the KCNQ1 gene highlights the importance of extending these studies to a wider range of populations.